Publications

(38). Balan, S., Iwayama, Y., Ohnishi, T., Fukuda, M., Shirai, A., Yamada, A., Weirich, S., Schuhmacher, M. S., Vijayan, D. K., Endo, T., Hisano, Y., Kotoshiba, K., Toyota, T., Otowa, T., Kuwabara, H., Tochigi, M., Watanabe, A., Ohba, Maekawa, M., Toyoshima, M., Sasaki, T., Nakamura, K., Tsujii, M., Matsuzaki, H., Zhang, K. Y. J., Jeltsch, A., Shinkai, Y., & Yoshikawa, T (2021), A loss of function variant in SUV39H2 identified in autism spectrum disorder causes altered H3K9-trimethylation and dysregulation of protocadherin β cluster genes in the developing brain, Molecular Psychiatry, 10.1038/s41380-021-01199-7

(37). Hara, T., Toyoshima, M., Hisano, Y., Balan, S., Iwayama, Y., Aono, H., Futamura, Y., Osada, H., Owada, Y., & Yoshikawa, T. (2021), Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons, Translational Psychiatry, 11, 275

(36). Ohnishi, T., Kiyama. Y., Arima-Yoshida, F., Kadota, M., Ichikawa, T., Yamada, K., Watanabe, A., Ohba, H., Tanaka, K., Nakaya, A., Horiuchi, y., Iwayama, Y., Toyoshima, M., Ogawa, I., Shimamoto-Mitsuyama, C., Maekawa, M., Balan, S., Arai, M., Miyashita, M., Toriumi, K., Nozaki, Y., Kurokawa, R., Suzuki, K., Yoshikawa, A., Toyota, T., Hosoya, T., Okuno, H., Bito, H., Itokawa, M., Kuraku, S., Manabe, T., & Yoshikawa, T. (2021), Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia, EMBO Molecular Medicine,13:e12574

(35). Ogata, S., Hashizume, K., Hayase, Y., Kanno, Y., Hori, K., Balan, S., Yoshikawa, T., Takahashi, H., Taya, S., & Hoshino, M. (2021), Potential involvement of DSCAML1 mutations in neurodevelopmental disorders, Genes to Cells, 10.1111/gtc.12831

(34). Balan, S., Ohnishi, T., Watanabe, A., Ohba, H., Iwayama, Y., Toyoshima, M., Hara, T., Hisano, Y., Miyasaka, Y., Toyota, T., Shimamoto-Mitsuyama, C., Maekawa, M., Numata, S., Ohmori, T., Shimogori, T., Kikkawa, Y., Hayashi, T. & Yoshikawa, T. (2021) Role of an atypical cadherin gene, Cdh23 in prepulse inhibition and implication of CDH23 in schizophrenia, Schizophrenia Bulletin, 47; 4, 1190–1200.

(33). Shimamoto-Mitsuyama, C., Nakaya, A., Esaki, K., Balan, S., Iwayama, Y., Ohnishi, T., Maekawa, M., Toyota, T., Dean, B., & Yoshikawa, T. (2021), Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression, Cerebral Cortex, 31; 1, 448–462

(32). Hayase, Y., Amano, S., Hashizume, K., Tominaga. T., Miyamoto, H., Kanno, Y., Ueno-Inoue, Y., Inoue, T., Yamada, M., Ogata, S., Balan, S., Hayashi. K., Miura, Y., Tokudome. K., Ohno, Y., Nishijo, T., Momiyama. T., Yanagawa, Y., Takizawa, A., Mashimo, T., Serikawa, T., Sekine, A., Nakagawa, E., Takeshita, E., Yoshikawa, T., Waga, C., Inoue, K., Goto, Y., Nabeshima, Y., Ihara, N., Yamakawa, K., Taya, T., Hoshino, M. (2020) Down Syndrome Cell Adhesion Molecule Like-1 (DSCAML1) links the GABA system and seizure susceptibility, Acta Neuropathologica Communications 8:206

(31). Wada, Y., Maekawa, M., Ohnishi, T., Balan, S., Matsuoka, S., Iwamoto, K., Iwayama, Y., Ohba, H., Watanabe, A., Hisano, Y., Nozaki, Y., Toyota, T., Shimogori, T., Itokawa, M., Kobayashi, T., & Yoshikawa, T. (2020),Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia, EBioMedicine 62, 103130 (*equal contributions)

(30). Maekawa, M., Ohnishi, T., Toyoshima, M., Shimamoto-Mitsuyama, C., Hamazaki, K., Balan, S., Wada, Y., Esaki, K., Takagai, S., Tsuchiya, K, J, Nakamura, K., Iwata, Y., Nara, T., Iwayama, Y., Toyota, T., Nozaki, Y., Ohba, H., Watanabe, A., Hisano, Y., Matsuoka, S., Tsujii, M, Mori, N., Matsuzaki, H., & Yoshikawa, T. (2020), A potential role of fatty acid-binding protein 4 in the pathophysiology of autism spectrum disorder, Brain Communications,10.1093/braincomms/fcaa145

(29). Ulahannan, J. P., Narayanan, N., Thalhath, N., Prabhakaran, P., Chaliyeduth, S., Suresh, S. P., Mohammed, M., Rajeevan, E., Joseph, S., Balakrishnan, A., Uthaman, J., Karingamadathil, M., Thomas, S. T., Sureshkumar, U., Balan, S., & Vellichirammal, N. N (2020) A citizen science initiative for open data and visualization of COVID-19 outbreak in Kerala, India, JAMIA, 10.1093/jamia/ocaa203

(28). Esaki, K., Balan, S., Iwayama, Y., Shimamoto-Mitsuyama, C., Hirabayashi, Y., Dean, B. & Yoshikawa, T.* (2020), Evidence for Altered Metabolism of Sphingosine-1-phosphate in the Corpus Callosum of Patients with Schizophrenia, Schizophrenia Bulletin, 10.1093/schbul/sbaa052

(27). Shimamoto-Mitsuyama, C., Ohnishi, T., Balan, S., Ohba, H., Watanabe, A., Maekawa, M., Hisano, Y., Iwayama, Y., Owada, Y., & Yoshikawa, T. (2020), Evaluation of the role of fatty acid-binding protein 7 in controlling schizophrenia-relevant phenotypes using newly established knockout mice. Schizophrenia Research, 217:52-59

(26). Ide, M., Ohnishi, T., Toyoshima, M., Balan, S., Maekawa, M., Shimamoto-Mitsuyama, C., Iwayama, Y., Ohba, H., Watanabe, A., Ishi, T., Shibuya, N., Kimura, Y., Hisano, Y., Murata, Y., Hara, T., Morikawa, M., Hashimoto, K., Nozaki, Y., Toyota, T., Wada, Y., Tanaka, Y., Kato, T., Nishi, A., Fujisawa, S., Okano, H., Itokawa, M., Hirokawa, N., Kunii, Y., Kakita, A., Yabe, H., Iwamoto, K., Meno, K., Katagiri, T., Dean, B., Uchida, K., Kimura, H., & Yoshikawa, T.* (2019), Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology, EMBO Molecular Medicine, 11:e10695

(25). Toyoshima, M. * , Jiang, X.* , Ogawa, T. , Ohnishi, T. , Yoshihara, S. , Balan, S., Yoshikawa, T., & Hirokawa, N.; Enhanced Carbonyl Stress Induces Irreversible Multimerization of CRMP2 in Schizophrenia Pathogenesis, Life Science Alliance 2, 5 e201900478

(24). Ohnishi, T., Balan, S., Toyoshima, M., Maekawa, M., Ohba, H., Watanabe, A., Iwayama, Y., Fujita, Y., Tan, Y., Hisano, Y., Shimamoto-Mitsuyama, C., Nozaki, Y., Esaki, K., Nagaoka, A., Matsumoto, J., Hino, M., Mataga, N., Hayashi-Takagi, A., Hashimoto, K., Kunii, Y., Kakita, A., Yabe, H., 2 & Yoshikawa, T. (2019), Investigation of betaine as a novel psychotherapeutic for schizophrenia, EBioMedicine, 45, 432-446 (*equal contributions)

(23). Balan, S., Toyoshima, M., & Yoshikawa, T., (2019), Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia. Neurobiology of Disease, 131:104162

(22). Maekawa, M., Ohnishi, T., Balan, S., Hisano, Y., Nozaki, Y., Ohba, H., Toyoshima, M., Shimamoto, C., Tabata, C., Wada, Y., & Yoshikawa, T. (2019), Thiosulfate promotes hair growth in mouse model. Bioscience, Biotechnology, and Biochemistry, 83(1):114-122

(21). Shimazu, T., Furuse, T., Balan, S., Yamada, I., Okuno, S., Iwanari, H., Suzuki, T., Hamakubo, T., Dohmae, N., Yoshikawa, T., Wakana, S., & Shinkai, Y. (2018), Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions. Scientific Reports, 8:1179

(20). Maekawa, M., Watanabe, A., Iwayama, Y., Kimura, T., Hamazaki, K., Balan, S., Ohba, H., Hisano, Y., Nozaki, Y., Ohnishi, T., Toyoshima, M., Shimamoto, C., Iwamoto, K., Bundo, M., Osumi, N., Takahashi, E., Takashima, A., & Yoshikawa, T. (2017), Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Translational Psychiatry, 7, e1229

(19). Balan, S., Yamada, K., Iwayama, Y., Hashimoto, T., Toyota, T., Shimamoto, C., Maekawa, M., Takagai, S., Wakuda, T., Kameno, Y., Kurita, D., Yamada, K., Kikuchi, M., Hashimoto, T., Kanahara, K., & Yoshikawa, T. (2017) Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia, Schizophrenia Research, 185, 33-40

(18). Toyoshima, M., Akamatsu, W., Okada, Y., Ohnishi, T., Balan, S., Hisano, Y., Iwayama, Y., Toyota, T., Matsumoto, T., Itasaka, N., Sugiyama,S., Tanaka, M., Yano, M., Dean, B., Okano, H., & Yoshikawa, T. (2016), Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Translational Psychiatry, 6, e934

(17). Maekawa, M., Iwayama, Y., Ohnishi, T., Toyoshima, M., Shimamoto, C., Hisano, Y., Toyota, T., Balan, S., Matsuzaki, H., Iwata, Y, Takagai, S., Yamada, K., Ota. M. Fukuchi, S., Okada, Y., Akamatsu, W.,Tsujii, M., Kojima, N., Owada, Y., Okano, H., Mori, N., & Yoshikawa, T. (2015), Investigation of SLC27A3 and SLC27A4 genes encoding for fatty acid transporters in autism: hyper-polymorphic nature and functional analysis. Scientific Reports, 5, 16239.

(16). Maekawa, M., Yamada, K., Toyoshima, M., Ohnishi, T., Iwayama, Y., Shimamoto, C., Toyota, T., Nozaki, Y., Balan, S., Matsuzaki, H., Iwata, Y., Suzuki, K., Miyashita, M., Kikuchi, M., Kato, M., Okada, Y., Akamatsu, W., Mori, M., Owada, Y., Itokawa, M., Okano, H., & Yoshikawa, T. (2015). Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses. Biological Psychiatry, 78, 116-125.

(15). Bangel, F. N., Yamada, K., Arai, M., Iwayama, Y., Balan, S., Toyota, T., Iwata, Y., Suzuki, K., Kikuchi, M., Hashimoto, T., Kanahara, N., Mori, N., Itokawa, M., Stork, O., & Yoshikawa, T. (2015) Genetic analysis of the glyoxalase system in schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 59, 105–110.

(14). Balan, S., Iwayama, Y., Yamada, K., Toyota, T., Ohnishi, T., Toyoshima, M., Shimamoto, C., Ide, M., Iwata, Y, Suzuki, K., Kikuchi, M., Hashimoto, T., Kanahara, N., Yoshikawa, T. & Maekawa, M. (2015). Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia. Journal of Neural Transmission, 122, 477-485.

(13). Balan, S., Iwayama, Y., Maekawa, M, Toyota, T., Ohnishi, T., Toyoshima, M., Shimamoto, C., Esaki, K., Yamada, K., Iwata, Y, Suzuki, K., Ide, M., Ota. M. Fukuchi, S., Tsujii, M., Mori, N., Shinkai, Y. & Yoshikawa, T. (2014), Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHMT2 and WIZ, in Japanese autism subjects. Molecular Autism, 5, 49.

(12). Sathyan, S., Koshy, L., Balan, S., Eashwer, H. V., Premkumar, S., Nair, S., Bhattacharya, R. N., Allapat, P. J., Banerjee, M. (2014). Association of Versican (VCAN) gene polymorphism rs251124 and rs2287926 (G428D), with intracranial aneurysm. Meta Gene, 2, 651-660.

(11). Balan, S., Iwayama, Y., Toyota, T., Maekawa, M., Toyoshima, M. & Yoshikawa, T. (2014). 22q11.2 deletion carriers and schizophrenia-associated novel variants. The British journal of psychiatry, 204, 398-399.

(10). Balan, S., Bharathan, S. P, Vellichirammal, N. N., Sathyan, S., Joseph, V., Radhakrishnan, K. & Banerjee, M. (2014). Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance. PLOS ONE, 9, e89253.

(9). Balan, S., Sathyan, S., Radha, S. K., Joseph, V., Radhakrishnan, K. & Banerjee, M. (2013). GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures. Pharmacogenetics and Genomics, 23, 605-610.

(8). Balan, S., Yamada, K., Hattori, E., Iwayama, Y., Toyota, T., Ohnishi, T., Maekawa, M., Toyoshima, M., Iwata, Y., Suzuki, K., Kikuchi, M. & Yoshikawa, T. (2013). Population-Specific Haplotype Association of the Postsynaptic Density Gene DLG4 with Schizophrenia, in Family-Based Association Studies. PLOS ONE, 8, e70302.

(7). Balan, S., Yamada, K., Iwayama, Y., Toyota, T., Ohnishi, T., Maekawa, M., Toyoshima, M., Iwata, Y., Suzuki, K., Kikuchi, M., Ujike, H., Inada, T., Kunugi, H., Ozaki, N., Iwata, N., Nanko, S., Kato, T. & Yoshikawa, T. (2013). Lack of association of EGR2 variants with bipolar disorder in Japanese population. Gene, 526, 246-250.

(6). Balan, S., Radha, S. K., Sathyan, S., Vijai, J., Banerjee, M. & Radhakrishnan, K. (2013). Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. Gene, 526, 449-453.

(5). Jain, N., Joseph, R., Balan, S., Arun, R. & Banerjee, M. (2013). Association of interleukin-4 and interleukin-17F polymorphisms in periodontitis in Dravidian ethnicity. Indian Journal of Human Genetics, 19, 58.

(4). Balan, S., Vellichirammal, N. N., Banerjee, M. & Radhakrishnan, K. (2012). Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Epilepsy Research, 101, 288-292.

(3). Vijayan, N. N., Mathew, A., Balan, S., Natarajan, C., Nair, C. M., Allencherry, P. M. & Banerjee, M. (2012). Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective. Pharmacogenomics, 13, 1119-1127.

(2). Das, A., Balan, S., Banerjee, M. & Radhakrishnan, K. (2011). Drug resistance in epilepsy and the ABCB1 gene: The clinical perspective. Indian Journal of Human Genetics, 17, S12.

(1). Das, A., Balan, S., Mathew, A., Radhakrishnan, V., Banerjee, M. & Radhakrishnan, K. (2011). Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene? Indian Journal of Human Genetics, 17, S41.